I took it to mean "not have a pickup selector" (i.e. all 3 permenantly on), in which case my answer is "No, it will sound like sh!t"
Unless he means "coil splitting on positions 2 & 4 of a 5-way switch", in which case my answer is "It's a matter of personal choice, I'd only use those two positions rarely for clean sounds so it wouldn't make any difference to the guitar's main sounds"