In terms of wiring, 4 Conductor is only necessary for coil cut, phase reversal, etc. Djent usually doesn't need too much of that but 4 conductor can become 2, 2 can't become 4 (unless you take the pup apart).
2 Conductor is just for standard wiring (LP-style 3-way) the braided shielded wire that Tim uses is reaaaaalllllyyyyy nice. You can get some decent combos too with a 5 way superswitch. Like for example, I have Neck, Neck Direct to Jack (slight boost), Middle, Bridge, Bridge Direct to Jack.
It all depends on what your looking for.