I'm currently using a vintage/low output neck and modern/hi output bridge, and I kind of like this combo for the moment, even if the difference is a bit drastic. Playing with the volume and tone pots on the middle position gives quite a wide range of (interesting) tones and makes for a very versatile guitar. I first tried a low output bridge (RR), was pretty good but didn't worked that well with my rig for the higher-gain tones I was after, but I have to admit I'm a bit spoiled by 15 years of hi-output 'buckers. Can't really afford another axe ATM, but I'd like to get me some 335-like semi-hollow mounted with vintage / low-output BKPs (SM or Mules).
It's worth mentioning that the lower output models are considerably less forgiving than the hotter and more compressed pickups in the range
When I first tried the Crawlers, I already found them to be quite unforgiving, but they're nothing compared with the (hotter) ABomb bridge. Also and FWIW, I would even consider the Mule neck as the most "forgiving" of the BKP buckers I tried, so it may not be only related to compression but also voicing, bass response and how much definition the pup maintains under higher gain.
Just my 2 cents...