An IT in the bridge paired with Trilogies would provide quite a difference in output and character. It's not the combination that immediately comes to mind. Anyway, if you're used to a Sinner, it will be a dramatic step back in high gain tones. A lower output singlecoil can not produce the modern leadtones of the ultrahot Sinner. I like my IT's for cleans and vintagehot soloing, but in both my strats I have a humbucker in the bridge for leads (Crawler and VHII). Maybe you can compromise by replacing the middle- en neckpickups by IT's or Slowhands. They sure are good for clean stuff.