Well, I think it is not that insane...Gilbert often playes kinda bluesy (and his live tone was just amazing).
Question is, are you talking about sinlge coils or humbuckers.
I would assume SC as the two you named use SCs. For that the Irish Tour or the Slowhand (the vintage hot range basecally) will probably be a good bet. The character fits and the rest will mostly be the amps gain to get the sound from Mayer to the more gainy saturated Gilbert.