The MM's handle gain well. I have a HSS-strat with two MM's and a VHII in the bridge.
The singlecoils ooze Frusciante. However for Gilmour Slowhands would be good choiche, but they are way middier and hotter. I think Irish Tours (these are in my other HSS-strat) could be a good compromise: they have more bass and beef then the Mother's Milk, but if you turn the vol.knob on the guitar a tad down, you're entering MM-terrority with the sparkle en bell's you're after. They sound less woody then the MM's, but you can get close with these. As I said: best of both worlds.