Yes, I've used Graph Tech saddles on both tune-o-matics and Fender bridges.
They're good, I think they change the tone slightly, mostly in the initial "attack" when you pick a string which seems to be softened a little. In something like a 345 I think that could be a good thing as I find they tend to sound quite bright on the treble strings.
You need to be careful to pick the right saddles, they make quite a few different ones but there's quite a good guide on their website.