I have both an alnico and a ceramic Nailbomb in each of my Les Pauls. The alnico one is in an Epiphone Les Paul Standard, mostly used in Standard tuning/drop D, drop C# and also Drop c (acts as backup to my main band guitar). I use 10-52's on this and its pretty solid in the tunings.
The ceramic nailbomb is in my main guitar (LP studio) and is in drop c tuning with EB 12-56's.
Its a great pickup though I am keeping an eye open for what else could go in the guitars, but for now its good for me.
It depends on the guitar you have an amp, etc etc which also affect the tone.