Are your Cold Sweat and Trilogy of similar volume?
Just as some background. I have a Hamer USA Mirage (3 single coil pickups, no pickguard) which has a mahogany body and koa top. I had Lace chrome domes which were dark enough but were too sterile sounding and I now have Kinmans which sounded great in my Strat but are just too bright for the Mirage. I'm looking to make this guitar a little darker and a little more powerful than a Strat but stille retain some single coilness. I'm trying to capture a horn like tone but with a broader spectrum than an HB. I will then put the Kinmans back in my Strat where they belong.
I have a Hamer FM Studio with Swineshead humbuckers in it that are the sweetest, singingest HBs I've ever played. They are not powerful by HB standards but have plenty more output than an SC. If the Trilogy suite has that kind of power I can deal, but if it's more powerful than that I think they will be to boomy.
Also, Is that your setup? That's quite a nice looking rig there!