I had a guitar wired so that the middle pickup wasn't reverse wired and it sounded thin and unpleasant to me, so I rewired it. It's only been the one time though.
It depends on the phase and also if you wire it in series or parallel. The Brian May switching lets you hear some of the series combinations and some of them do sound really bad!
I have both types of centre pickup in my strats, but find that I prefer the non-rwrp. You can set up the switching of an H/S/H guitar to give you automatic coil split if you want. I am setting mine up to give me the following:
Bridge HB
Bridge screw coil and neck screw coil in series
Both HB's (coils in series, pickups in parallel)
Bridge Stud coil and neck Stud coil in parallel
Neck HB
I am having a separate mini toggle to let me have the single coil by itself, with whatever other combination is selected, or by passed.
If you use a 5-way 4-pole super switch you can set up almost anything you want. Add a 3-way 4-pole switch and you really do have the ability to change everything.
if you have a MQ neck then you rally have a H/S/S set up. I usually have this as:
bridge HB,
bridge screw coild and middle
bridge stud and neck (like a tele in the centre position)
middle and neck
neck
Hope this helps, you can also check
http://www.guitarelectronics.com, they have some good wiring hints.
