Thanks for the help everyone.
Basically, I'm after the infamous Eddie Van Halen sound, not because I want to emulate him (ok, maybe I do lol), but because the sound really, really appeals to me. But I also want the flexability to get a deep grungy punk sound, along with also getting the beautiful cleans of a great Strat.
I know it's a lot to ask, but hey, that's what makes it so fun. I've got the 5 selector switch, so I don't mind doing a little re-wiring if I can make use of its functionality to mix/match.
If you guys think a H/S/S or H/S/H would get me there as opposed to a S/S/S, I guess I'll break down and consider that. So, what PUPs/combinations do you recommend for my MIM Lefty Strat?