When I was at ACM, Dave Kilminster (now playing for Roger Waters) used to get the sickest pinched harmonics from single coil guitars, so it can be done.
I get good ones from my Strat too, but I do have to pile on the gain to get it to really scream. I know a guy called Jim Clark who has Trilogy Suites in his Strat (I believe) and he always had a killer tone. He'd play a lick on the neck pickup, and as he hit the last note, he'd flip onto the bridge and nail a wide vibrato, and the guitar just wailed. So they get my vote.