infront of clean --> more volume with possibility of crunch
infront of dirty --> more distortion
in fx loop --> more volume whether clean or dirty.
i personally have 3 channels on my amp (clean crunch lead), so i just dial in lead to sound like crunch, but with more volume... so for me, i'd use it in front of the amp to get some more gain out of it... because hell, my amp is loud enough by itself hahaha.