They are the best Strat pickups about in my view (well, I prefer Mother's Milks by a milimeter or so) - I have a set in a Mexican 60s classic - the difference between the whiny, trebly stock pickups and the Apache is night and day. Also they don't feedback uncontrollably like the stock Mex fenders unless you whack up the gain to full.
I have a home modded DS1 based on the Monte Allums tri gain circuit - if that is what the Keeley is like, its an extreme modern distortion that is going to colour the sound of any guitar. My Apaches still work well with it, though, especially on the LED based gain.
As to hot-ness - I genuinely believe that the secret of good strat tone is having weaker pickups - you have to work harder - but that classic Hendrix or SRV type strat distortion comes from a cranked amp, not hot pickups. Apaches are not underwound by any stretch - compared to real 50s strat pickups they are in a genuine but hotter zone of that era.
To my ears, when compared to the Mother's Milk set, the Apaches are much ruder and have a more rich and bluesy distortion when cranked - in a maple necked 50s classic they are going to rule.