As other posters have said, they feel different, perhaps a little more tension on the Fender scale with the same gauge of strings. Perhaps people with really large hands might find the upper frets on a Gibson uncomfortable with not enough "room", but mostly it's a matter of personal preference & few guitarists should find any of the three most common scale lengths (24¾", 25" & 25½") unplayable. IMO action height, fretwire & neck profile have just as much, maybe more, influence on perceived comfort of a guitars as scale length.
FWIW, I have guitars in all 3 scale lengths & happily swap between all of them. Sure, there are somethings that are easier to play on one guitar than another, just as some guitars sound better for certain uses. Horses for courses.