Does your friends Strat have a rosewood neck? I find that the rosewood gives a mellower sound over the maple. I have a set of Irish Tours in a swamp ash body/maple necked hardtail strat, but I am thinking of putting a rosewood neck on it because it is a bit bright. I am just waiting for my Apache set to come (for a different guitar).
Tim always says the difference between the IT and Slowhand is the Texas vs English blues tone (even though Rory is Irish :lol: ). I also have a Slowhand that I might try in it to see how it compares (the slowhand is for a walnut guitar, but it is still in transit from England). The Mothers Milk should work well in an Ash/Maple setup too.
I also have a HSS set with Nailbomb and 2 Trilogies. This is a great combination for more power and a fatter tone. The Crawler is a great pickup and splits well (I have mine with 2 P-91's in a PRS EG). If your guitar has the swimming pool rout, changing to HSS is easy and you can just get a new scratchplate. If it is routed for 3 singles, then it needs some woodworking skills.
As always, listen to a few clips and ask Tim. He has lots of pickups that will give you a great sound.