I'm sure a number of you guys use Guitar Pro, and i've often wished that i didn't have to fiddle about changing amps/effects (mostly through pure laziness), whilst i'm trying to learn a song in front of the computer... so i've solved the problem by having GP change all the patches in my rig (MIDI enabled, but you could have a simple interface to do a regular amp).
I've written
a brief article on how to do it, and although it's fairly niche by being Mac-specific, the principles behind it are the same, and i'm sure there must be a Windows equivalent of the MidiPipe utility.
Hopefully it is of interest to some, even if it just promotes thought on a similar train :) This leaves the door wide open for things like sequencing in other programs, like Logic or Cubase, which may trigger an idea that you'd like to explore.
(i thought it best suited this forum because although its techy, it's to do with amps and effects :))