I used to have a mate that used the line "'ello luv, do ya $%&#?". It worked more times than you would expect, but the best response I heard was "yes but not with someone like you". His theory was he wouldn't be wasting money buying drinks if they said no!
The absolute worst line I ever heard was 'You must have a lovely bush", though to be fair the girl looked like she would have (unfortunately that wasn't the right answer when she complained to me! If I'd had less to drink and had been sympathetic I was probably in there!).
In the 70's I scored a few times with the old 'I bet you 10p I can make your tits wobble without touching them' line (it been worth 10p to feel the tits anyway). I went out with a girl for 2 years who I picked up by sticking my cold hands inside her halter neck top (she did hit me at first - but apologised to me when she saw me later, saying she had to hit me because she was with her friends! Interestingly one of her friends also came over to talk to me too).
Nowadays I am so used to women picking me up that I don't have good opening lines :P
