I presume you have checked out Andrew W's lovely Black Telecaster pictures and sound clips in the player's section:
" Mexican Tele with Mississipi Queen and Piledriver " ? If not, it's worth a look / listen.
I am a M.Q fan, and as Copperhead believes the routing behind the scratch plate would support a M.Q's dimensions, I can imagine it would sound great - as the M.Q. is a pickup I have enjoyed in other types of guitar, and would love to 'kit out' a Telecaster with one in the neck.
Just a ( biased ) thought. :)