Which do you prefer? HSH or HSS? What pickups do you use in this combination? Why do you use them pickups in this combination?
I think this would be helpful for a lot of people who mix and match pickups with these 2 pickup routings :)
Never had any of these combos, but from experience with SSS and HH, I'd rather go for HSS (now I already have two HH guitars and no more strat-like ATM so I may be a bit biased ;)).
wrt/ "which pickups", it first depends on your guitar, tastes, playing style(s), rig and whatnot, so I don't think there's any valid "One size fits all" answer. On a HSS strat I would probably go for a Crawler or VHII bridge and MM or IT singles, but the only educated choice here is the Crawler bridge which I already have (on a bright HH guitar) and really love for it's warm, rich, thick, singing yet clear and detailed tone, and overall versatilty.