foster, getting some a Black Dog/Mule is a world of difference between the Gibson 500t/496R... absolutely no comparison. The Gibson 500t/496r set is ceramic, and fairly compressed and too harshly voiced to play with the gain down... closest BKP to it is the Miracle Man which is one of the few BKPs that is fairly limited to more or less one sound....
I had the same pickups in my Les Paul once. They do the whole Zakk Wylde thing, but if you want a classic Les Paul like tone, they will not deliver. Mules, Black Dogs, the combo you mentioned, or even Rebel Yells or the overwound but still Alnico V magnet Nailbomb set will do a lot better job. The difference is like night and day.