`Tis what I am running. In a P90 / HB setup (MQ / Crawler) the neck is noticably brighter in the top end, but not harsh or brittle. SC character coming through, but full like a HB. Lovingly balanced. Manhattan neck is brighter yet, which is great for strummy cleans, and it can go down to singing no issue like that. The distortion with the tone a bit down is so psychedelic. My Supermassive Stockholm set I almost always have on full, but the pots still work.
Should that run into issues, especially if you have a hard time finding sweet spots on the tone: The taper on the tone pot is of quite a bit of consequence, plus 50s wiring or a treble bleed. The 50s especially changes the feel of the pots a lot.