I also had a PRS SC250 from 2007, also chambered, and I also found it to be incredibly fussy with pickups. I could not get it to sound anything close to how I liked, and a lot of that was the acoustic tone of the guitar, it had a very stiff attack. Switching from 10-52 to 9s just on that guitar made a massive difference, weirdly!
It had all kinds of pickups in it - Dimarzio, Bare Knuckle, Oil City, Suhr.... and in the end it was happiest with the stock pickups, which weren't fantastic but weren't awful either, and suited better than anything else. Pickups that I loved in other guitars just would not get on with it. The second happiest in it were a set of Oily City Scr@pyard Dogs, so the closest BKPs to that kind of design would be the Riff Raffs.