Hi, the mule will hold its own against the MM neck and will balance well with the MM bridge. Tonally to these ears the Mule has a vintage voice, a warm round tone and loads of sustain. Whereas the MM neck is full sounding but alot brighter and more gain, the mule can handle as much gain as you want to throw at it but is more of an all rounder. I have had the MM set and currently the Mule set in a les paul, i went with the Mules because they fitted my blues/rock/metal/clean needs and the MM where more focused on the metal tones. My opinion.