I'll talk in favor of acrylic bodied guitars. I had one for a short time and it sounded really great, very fat and organic sound. It had a suprisingly heavy accoustic sound, very defined, it's like a denser mahognay with more bite.
So a nicely made acrylic guitar can sound good, most of those are cheapos, I think that's why they sound like cr@p.
The downside is acrylic is a VERY HEAVY material, so beware...
All of you guys should try one if you have the occasion, and I, myself, am owner of some exotic woods guitars, so I relatively know something about woods hehe.