Crackling and popping is usually associated with power tube wear.
this is off the MESA site and is always useful;
Signs of Wear 
Power Tubes:
•  Low end response is not as clear and distorts earlier.
•  You turn your amp’s master volume up to hear the level that
   you are used to hearing.
•  Eventually you will hear 'crackling' 'popping' sounds, often accompanied by:
•  'Swelling' volume levels. 
•  Buzzing.
Preamp Tubes:
•  Hissing, 'shooshing'.
•  Sputtering, 'grumbling'.
•  Microphonic squealing (feedback type sound).
•  Loss in signal in one or more modes of the amp (channel, reverb, fx-loop).