I've tried my Mules with a 250K volume pot in my Strat before but didn't like the results, even without a tone pot. I can achieve a smoother tone with heavier strings (12's instead of 10's) but without sacrificing highs and dynamic range. I prefer the more open sound I get with a 500K volume pot. If I need more 'air' and a smoother attack, I lower the pickups and turn up the gain a little bit to compensate. BTW, the volume pot in my Artist is jumpered and wired so that it's variable between 720K and 220K and I definitely prefer the 500+ range to the lower settings.