I have the Nailbomb bridge and Cold Sweat neck in an Ibanez, with an Irish Tour in the single coil position. I put a 3 way mini toggle in to switch the IT in and out (gives in by itself/with the 5-way/out), and then put PRS style wiring on the 2 humbuckers. I am a rock/blues player more than a metal player, however this setup does sound great. I can go from a heavy biting crunch all the way to a Dave Murray lead tone if I run the gain high, or get a great single coil tone with just the IT and the volume backed off, and then go into the more classic rock tones from the humbuckers. The great thing with BK's is that you don't lose clarity when you back off the volume.
I have also played an Ibanez with 2 Warpigs and a Trilogy, which was insane for heavier stuff but could clean up really nicely.