The studio has the fat 50s neck profile, which puts some people off. The pickups are the 498T/490R set, the standard has burstbuckers. Also, I've heard that the body is slightly smaller on a studio but it's not something I'd notice unless I had both guitars by me at the same time. And with Gibson, it's very difficult to find a good one of each model for comparing.
The one in the link is a "faded" model of the studio. I've seen it in stores, but oddly not on the Gibson website.