Think about getting an ISP G-string noise gate (or the Pro rack G). It is, in my opinion, the best noise reduction around. It has two circuits, one for stuff coming into the input of the amp, and another for the FX loop. If it's a problem in your pre-amp or in your effects, cables, or guitar, it will definitely help. If not... well, it won't hurt, and it'll definitely help you narrow down the source of the hum by isolating different parts of your rig.
Also, even if you don't have spare cables lying around, try swapping the order of your cables in your effects chain, and listen for changes in the hum.