I use my tone controls all the time.
Years ago (with a strat) I learnt to set up my amp tones with more top-end than I need then roll it back on the guitar tones - gives you the feeling of loads of versatility from your guitar alone.
I learnt this off watching Rory Gallagher live several times in the late 70s and early 80s. In an interview in the mid-late 70s he said he turned all the bass down, all the treble and mids up, all the volume up, and then used his guitar controls. It worked for me for while, but I find those settings a little extreme nowadays!