I've got Hot 100s in my 4x12 and 2x12, which I often run together as a 3/4 stack. Individually I prefer how my 2x12 sounds, despite the fact that it's got the same speakers in it, and is made from the same wood.
I like the Hot 100s because of the clarity of sound, combined with the rich bottom end I get using them. I used to use a 1960 lead A style cab with G12-T75s and they were so toppy, I felt like they were slicing my head off!
I've got an open backed 1x12 with a Vintage 30 in it, which is good too, but perhaps a little nasal, for want of a better word.