Ah... I'm feeling more and more re-assured over the Vista thing :D
Are you still on a laptop with Vista Tom? I'm reasonably happy with latency on my XP laptop, but once a song gets a lot of tracks I have problems with what Cakewalk calls "DROPOUT" - basically the computer ain't got enough resources to keep up... Eventually I found out that what is restricting me is hard disk speed - most laptop drives run a fair bit slower than desktops, and considering the number of disc reads involved in playing back multi-track... :roll:
I like the look of the Power Studio 250 because it's got the user-interface I'm used to (updated, obviously), it wants Vista, and they've packaged it with what appears to be a well thought out audio interface with their name on it - so once you've convinced your PC it's taking the drivers, the two should most definitely work together!!
Oh yeah, and I TRUST Cakewalk bigtime... I've been wracking my brains, but I can't remember having a single crash or anything that's gone wrong at all with the Cakewalk Home Studio I'm using at the moment. The help files are comprehensive - I've always found out what I need to know - and their website is full of information (or at least it was, I assume it still is).
Bottom line though - if what you've got does the job, why change it? I'm only in the market when my laptop dies, fingers crossed that isn't too soon, but it can't be too long now, it's getting on 5 years old...