I use reverb for leads with my high gain RM100 head, but that's mostly with really low output stacked singles driving it for high gain blues-rock lead tones, not for uber-fast widdling. You're not going to want to use reverb if articulation is at a premium or if you have loose pickups or a loose amp, and you generally wont want to use it for rhythm, because it'll sound terrible, imo. Still, it never hurts to try :)