Big frets seem to add a bit more weight to the sound, and bends and vibrato are really very easy. Legato is nice and smooth too.
Small frets I find offer a different control when you're bending as you feel the fingerboard, they sound snappier and brighter with a touch more sustain as the point of contact between string and fret is smaller.
I find i play faster and smoother on jumbo as the fingerboard doesn't slow me down. 6105 wire is a good compromise. it's as tall as jumbo 6100 but not as wide. Ibanez fit 6105 to the JS and JEM guitars, as do PRS. I'm going over to 6000 super jumbo - it's even taller and wider, just to make my life easier!