It works well in a 2x12 too I believe, but not for me. Matchless use a G12M/G12H combination in their DC-30, and lots of the booteek guys do a similar thing. I've tried a couple of mixes in 2x12s, but never really loved the tone. I now use two Celestion Golds in my 2x12.
My 4x12 has two V30s and two G12H Heritages in a X-pattern, and this gives a great range and spread of tones.