My 2 pence:
There is little discernable difference between the Feline's I've played and own and a good example of a high end guitar from PRS, Gibson, Vigier etc.
If a major manufacturer happens to make a guitar that has exactly what you want in terms of spec, then you should buy it.
If you want something that is a slightly different spec and are prepared to wait longer; go to a luthier.
Many luthiers in the UK can build a guitar to the exact spec of the well known brands, to at least the same quality and at a lower price. Due to their smaller capacity, you have to wait longer :(
You get what you ask for. If you don't know 100% what you want then chances are you may be moving the guitar on at some point, as Twinfan pointed out be prepared to lose financially on the re-sale value of a custom build.
My top 3 guitars (potentially) are my Feline Lion, Musicman Axis SSport, then Feline Tiger, in that order.
Can't remember the prices at new, but it would be about £2,300, £1,250 and £1,900 at a guess. There can't be more than 10% difference in quality, but there is in price.
Likewise all of these 3 can absolutely piss on a lot of guitars I've played that weigh in at £3,000 plus.