Thanks for the helpful replies everyone, the answer has become clear after a pro set up and a lot of amp tinkering:
1. Get the setup and intonation right and bang a set of 11's on.
2. On the amp ( a Rivera on the Fender-ish channel), drop the mids a bit, bring the treble up a lot and reduce the bass to 5. Increase the master volume, drop the other volume a bit. Hey presto! Big, fat 57 Les Paul tone with clarity, chunky woody mids and a very deep, thick and dare-I-say-it pert bottom end. Somewhere between Peter Green on "Ramblin' Pony" and Billy Gibbons on "Brown Sugar". I just did a love wee in my pants.
Mike.