The tone of my question was more along the lines of "these things are so damned good, can they be bettered?"
For me, yes they can in certain areas. I have other brands that I prefer more in specific guitars. It's all about matching:
* Your playing style and tonal needs
* Guitar
* Pickups
* Amp
I still stand by my "everything's a compromise" stance, and I think the major difference between the tone of your 335 and your Lester is the guitar itself and not the pickups. 335s have that acoustic woodiness that you're not going to get from your average Les Paul.
It sounds to me like you would benefit from other 335 with hotter pickups (AIV SMs or AIV Mules) instead of two Les Pauls......