well i have to admit, the axefx isn't for everyone but if you invest in the time needed to become acquainted the results are extremely rewarding.
For me, i went from a huge rack rig to an axefx + 2/90/2 poweramp + cab and now to this.
I no longer need to mic up live so my tone is always spot on through front of house. This is with impulses taken from acoustically perfect studios I can only dream of being able to afford tracking in (redwirez). I hear this exact sound through my monitor and it sounds phenomenal.
I don't have to worry about tubes, I've cut down about 50kg of gear (on this upgrade) and freed up plenty of trailer space, my rig sounds identical at all volumes and its perfectly consistent everywhere I take it and from every angle. It disperses all the way across stage so i can hear myself without cranking the foldbacks. Also it sounds the same from wherever you are relative to the speaker unlike a guitar cab and moves WAY more air if you want it to.
Add to these benefits the fact that my 4 main patches are the best tones I've ever had, after about 4 hours of tweaking. The monitor makes a huge difference as does the impulses used. I couldn't nail a tone i liked with the stock IR's. Plus my axefx is 100% silent and 100% reliable. Seriously it was a no-brainer for me, I know its blasphemous not playing through a tube amp but if you set it up right it, for my application it can't be beat.