Yeah, the Klone really is a pedal that somehow works all the time. Basecally all settings have something about them that works in a way and they can be set to work with every amp and guitar I have ever tried them with, just like gwEm.
Mostly I do the "more" setting John recommended me and I love it. When I put that into a dirty amp it does just that, gives me more. More volume, more gain and mostly more of all that goodness.
The gain it produces has such a nice harmonical structure that it goes hand in hand nicely with the amps gain. Even if you turn off the gain completly you are still left with basecally a nice clean / treble boost.
Also it should be noted that the Klone is very transparent. With a TS type OD you always get mid humps and all that stuff, which can be great (I got one OD for that too, build by Toe Knee, also a great pedal for what it does), but it is not always and leaves its imprint upon the tone.
One way to put it is that the Klone does not do much to change your tone, it just picks out the best parts of it (whichever you want those to be) and multiplys them.
In the end it just sounds good and is so very usable. I use mine from fattening up cleans sounds to getting my blues on, getting the crunch going and pushing my amp into metal. It all works.
Plus John (Juansolo) is such a gent to deal with.