Yeah I think he went from the nailomb/cold sweat to a set of cold sweats to the cold sweat/mule.
I always thought wih the uge amounts of treble and bottom end it'd sound very Dimebagesque.
The thing about the ISP is I know it works well but the G String means you can use it in front of the amp and in the loop a the same time, handy as my pedals or power supply seem to be mega noisey and i wouldnt want to use 2 noise gates.