This is very interesting.
It seems there is always this tension between the tone we 'want' and the needs we have. Like being the only electric guitarist means wanting a really huge and 3D sound but the minute you have one or two other guitarists to work around, the frequency spectrum needs to narrow significantly to accommodate it. It's also the case where live, you don't want excess frequencies outside the mids just so that people can actually hear what is being played.
I find that when I'm the only player and I'm doing lower gain stuff, I like my Godin LG with Seymour Duncans. The guitar sounds 'thicker' and 'beefier' for this sort of a sound, which is an asset. For high gain stuff, it gets muddy, sloppy, undefined, and very loose. The very things that I like about it become huge drawbacks once I start trying to work with a different genre.
The Les Paul sounds 'thin' and 'midrangey' for the low gain sounds but when I pile on the gain it is tight, articulate, bright, with great string separation and a wonderful pick attack. Perfect for High Gain.
I'm thinking of doing a warmoth project at some point and I've been thinking a lot about what I'd want an instrument to do that my other guitars do not do. A maple neck, rosewood fingerboard, and alder body sound like a good idea. I'd like an A-Pig or a Jugg in the bridge, I think. Hard to know what to do because I can't predict the tone of the guitar once built and then I can't predict how it would work with my amp. Reading these reviews gives a lot of ideas for sure but I'm still a bit fuzzy on what I'd like.