You mean twisted, or bowed? Bowed would just entail a truss rod adjustment and unless the rod is broken is easily fixed. If it's twisted that sounds like new neck time. Can you see the problem by eye?
With all weird tuning issues my first thought now is 'is the wah switched on?' One time a friend had been playing my guitar and left the wah switched on. The next time I played it I started with the tuner before switching the amp on and while five of the strings could be tuned as per normal the low E kept swinging wildly between tunings. I thought there was a problem with the tuning peg and took the string off before realizing that the wah was on. I felt pretty silly after that