I have a VHII set in my PRS Artist II, which is a 22 fret non-trem, so I think that it will sound exactly the same as you will get. It gives a great old PAF tone that is good for the Cream era Clapton sound but can clean up to give a David Gilmour tone, and gets very Fenderish in positions 2 & 4 on the rotary switch. When you get the pickups, if you have the PRS 5-way switch, be sure to tell BK. They will make the set with the magnet reversed in the neck so that you can get the correct humbucking sounds in the split selections.
The only other neck pickups I would think about with a VHII would be a Stormy Monday or Mule, but I think the stock set is really a great sound.