sambo, you and MDV are making the good point about working at the amp tone, as there's subtle interplay between many a knob on the Engls.( My old Marshall JTM as I remember did not have a middle, so the presence of one on the Engl has been a welcome change!)
I'd better qualify that my Engl is the Sovereign112 combo and I use the extension cab for larger venues(actually hardly ever as it happens at the mo); yes, it has bags of treble in reserve and I am very sparing with presence, though again the controls are deceptively subtle in their interplay. What with 2 master volumes as well as "soft" and "heavy" lead, there are differing tonal colours available depending on pre- and -post amping too.
As regards your enquiry about settings, well, I'm a middly sorty of chap for single note work: I keep bass, treble and presence all at zero(honestly there's enough inherently there) and middle at full on. The soft lead setting and lead volume I push hard, so as to have the beginnings of that compressed saturation at the pre-stage...as you can imagine, this succeeds in a fizz-free zone. Also, to be honest, what with the channel switching and the guitar's tone+vol, there's enough ready tonal width without adding anything else on the floor. If I want more, I just engage a wah c--ked in the bass position for more fruitiness, relying totally on the amp alone for overdrive. IF(hardly ever) I need to go into "triple rectal" pseudo-mode, I can flip into the amp's Heavy Lead setting, slide up the gain pot on the wah, and yowl like a tw@t. Don't get me wrong, I'm not an Engl fanboy but confess to being thoroughly thankful it's the type of amp that allows my guitars to speak with their natural voice: I found I was always trying to wrestle my Marshall into compromising compliance rather than relax into my playing.
