Was thinking a Warpig at the neck and a nailbomb at the bridge
OK, definitely
NOT that combo - WP neck would possibly overpower the NB bridge. If anything, the other way around would be better, however IMO the neck pickup is a secondary consideration here :)
IMO Miracle Man has the intensity, Painkiller would handle the extreme detuning very well. Warpig, or the custom Ceramic Warpig are popular for this kind of music (but I don't have either & would rather not recommend a pickup I haven't actually used).
A slightly left-of-field suggestion would be the Holy Diver - it's a pretty meaty pickup with a ton of low mids, huge single note definition & works really nicely for twin guitar harmonic work - I posted an IF-derived clip
here (OK, the guitar was only tuned to Eb, but you get the idea...)
Cold Sweat neck with high output bridge humbuckers is a popular combination or just go with a calibrated set of whatever bridge you choose - the BKP neck pickups are wound & voiced specifically to compliment the bridge pickups, not just the same pickup with the pole pieces the other way round.
BTW, I love In Flames - thanks for posting that video :)