No, it'll blow up earlier :o
4x12 with four 75w speakers = 300w power handling. With a 100w head, no problems.
4x12 with four 30w speakers = 120w power handling. With a 100w head fully cranked you're pushing the upper limit of the speakers. Add a pedal boost and you'll likely blow a speaker or several. EVH used to blow 25w Greenbacks with his 100w head on a regular basis.
A rule of thumb is to have twice the power in your cab as your head when using vintage style speakers. I use a 100w head with a 130w 2x12 but I don't run it fully cranked. Plus the Vintage 30s I use are generally able to withstand abuse better. Vintage spec speakers are much more delicate.
What speaker combination did you have in mind, and what amp are you using?