The difference is minimal if you have a steel block. Allparts make a vintage steel block trem which has the same sound as the callaham. The saddles will make a major difference in your sound. The vintage bent saddles have a ttoally different sound to the cast, which have a different sound to brass, which have a different sound to graphtech.........
I haven't tried titanium saddles, but would assume they have a sound of their own too.