I have Rebel Yells in the PRS and Holy Diver in a Warmoth superstrat with 2 Trilogy suites. The Rebel Yell is a brighter pickup and loves to give harmonic feedback. They both have a similar output, but the HD is more of an 80's style sound with a thicker tone. In a PRS with a 5-way, the parallel sounds (2 & 4), are almost Fender like in the clarity. Not having tried the HD in a PRS, I can't tell you what the sound would be like in there.
I play almost all blues and classic rock, with some heavier Zepplin and Black Sabbath, but not really any metal. I am in the lucky situation of having a lot of guitars with BK pickups, so I can select the sound I want in a guitar. My guitars are either strung 11-50 or 10-46 depending on the scale length.
I have several custom made recording amps, but my main higher power amp is a Marshall Silver Jubilee with an Ear Candy 1x12 extension cab. Both the combo and cab are fitted with Celestion Sidewinder speakers.
If you are wanting a thicker tone, depending how hard you play, the VHII is very good. It has a great bottom end and very nice lead tones. TO uses one for metal and they work really well in a PRS. I took mine out because I wanted a more classic sound in a PRS (my others have MM set, Crawler/P-90 and RY).
One thing to remeber is to tell BK that the pickups are going into a PRS, they build them with shorter legs and reverse the front pickup magnet to give the correct HB orientation with the 5-way settings.